Linkage analysis of chromosome 2q in osteoarthritis
نویسندگان
چکیده
منابع مشابه
Linkage analysis of chromosome 2q in osteoarthritis.
BACKGROUND In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA). OBJECTIVE To test chromosome 2q for linkage to idiopathic osteoarthritis. METHODS Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage dise...
متن کاملInvestigation of chromosome 2q in osteoarthritis of the hand: no significant linkage in a Tasmanian population.
BACKGROUND Previous studies have suggested a strong genetic component to osteoarthritis (OA), especially that of the hand, and three linkage studies have suggested the existence of susceptibility loci in disparate regions of chromosome 2q. OBJECTIVE To examine for linkage to 2q in a Tasmanian population of women and men with familial hand OA. METHODS Hand OA (distal interphalangeal, carpome...
متن کاملOguchi disease: suggestion of linkage to markers on chromosome 2q.
Oguchi disease is a rare autosomal recessive form of congenital stationary night blindness. The condition is associated with fundus discolouration and abnormally slow dark adaptation. Earlier studies suggested that the 48 kD protein S antigen may be involved in the recovery phase of light transduction. Previous cytogenetic and linkage studies have localised the S antigen gene (SAG) to chromosom...
متن کاملAssociation of two loci on chromosome 2q with nodal osteoarthritis.
OBJECTIVE To search for genetic association between microsatellite marker loci and sibling pairs with nodal osteoarthritis (NOA). METHODS Using the affected sibling pair method of analysis, genomic DNA from 66 sib pairs with NOA was analysed for association with highly polymorphic microsatellite marker loci. The microsatellite markers were amplified using polymerase chain reaction and typed o...
متن کاملanalysis of power in the network society
اندیشمندان و صاحب نظران علوم اجتماعی بر این باورند که مرحله تازه ای در تاریخ جوامع بشری اغاز شده است. ویژگیهای این جامعه نو را می توان پدیده هایی از جمله اقتصاد اطلاعاتی جهانی ، هندسه متغیر شبکه ای، فرهنگ مجاز واقعی ، توسعه حیرت انگیز فناوری های دیجیتال، خدمات پیوسته و نیز فشردگی زمان و مکان برشمرد. از سوی دیگر قدرت به عنوان موضوع اصلی علم سیاست جایگاه مهمی در روابط انسانی دارد، قدرت و بازتولید...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2000
ISSN: 1460-2172
DOI: 10.1093/rheumatology/39.4.377